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N-acetylcysteine

NAC

N-acetylcysteine

NAC

Mechanisms of action of N-acetylcysteine (NAC).

Increased activity of cystine–glutamate antiporter results in increased activation of metabotropic glutamate receptors on inhibitory neurons and facilitates vesicular dopamine release;

NAC is associated with reduced levels of inflammatory cytokines and acts as a substrate for glutathione synthesis.

These actions are believed to converge upon mechanisms promoting cell survival and growth factor synthesis, leading to increased neurite sprouting.

BDNF = brain-derived neurotrophic factor;
IL = interleukin;
NADP = nicotinamide adenine dinucleotide phosphate;
NADPH = reduced form of NADP;
TNF = tumour necrosis factor.

Quoted from Source & Featured Image Source:
ncbi.nlm.nih.gov – PMC – National Center for Biotechnology – US National Library of Medicine – National Institutes of Health
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
J Psychiatry Neurosci. 2011 March; 36(2): 78–86.

ncbi.nlm.nih.gov – Mechanisms of action of N-acetylcysteine (NAC)

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