Vitamin B-9, or folic acid, plays an important role in brain development and overall mental health, and folic acid deficiency can lead to birth defects and clinical depression.

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Folic acid contributes to the production of S-adenosylmethionine, or SAM, which is necessary for healthy neurological function.

These B vitamins cannot work well in the body without each other:

Folic Acid = Vitamin B-9 = L-Methylfolate

Pyridoxine = Vitamin B6 = Pyridoxal 5 Phosphate

Cobalamin = Vitamin B12 = Methylcobalamin

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9).

Some people have a genetic variation in the MTHFR gene that reduces the amount of activated folic acid in the body.

There are tests available to screen for a genetic variation in the MTHFR gene.

  • Inherent Health Nutritonal Needs Genetic Test $169.–
  • SpectraCell Laboratories MTHFR Genotyping $195.–

There are a number of options to get the vitamin activity that is equivalent to that of folic acid in your body.

  • Isotonix® Activated B-Complex’s Calcium Folinate  (Folinic acid, unlike folic acid, is not negatively impacted by this genetic variation.  Folinic acid is the highly bioavailable, metabolically active derivative of folic acid.)
  • Deplin® (L-methylfolate) is a medical food dispensed by prescription.

I found this site to be an expert resource on MTHFR Gene Mutations:

Quoted from Sources: – Folic Acid Brain
Genetics Home Reference
Inherent Health – Nutritional Needs Genetic Test
Interleukin Genetics – SpectraCell MTHFR Genotyping Lab Test
nutraMetrix® Isotonix® Activated B-Complex