Vitamin B-9, or folic acid, plays an important role in brain development and overall mental health, and folic acid deficiency can lead to birth defects and clinical depression.

Folic acid contributes to the production of S-adenosylmethionine, or SAM, which is necessary for healthy neurological function.

These B vitamins cannot work well in the body without each other:

Folic Acid = Vitamin B-9 = L-Methylfolate

Pyridoxine = Vitamin B6 = Pyridoxal 5 Phosphate

Cobalamin = Vitamin B12 = Methylcobalamin

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9).

Some people have a genetic variation in the MTHFR gene that reduces the amount of activated folic acid in the body.

There are tests available to screen for a genetic variation in the MTHFR gene.

  • Inherent Health Nutritonal Needs Genetic Test $169.–
  • SpectraCell Laboratories MTHFR Genotyping $195.–

There are a number of options to get the vitamin activity that is equivalent to that of folic acid in your body.

  • Isotonix® Activated B-Complex’s Calcium Folinate  (Folinic acid, unlike folic acid, is not negatively impacted by this genetic variation.  Folinic acid is the highly bioavailable, metabolically active derivative of folic acid.)
  • Deplin® (L-methylfolate) is a medical food dispensed by prescription.

I found this site to be an expert resource on MTHFR Gene Mutations:

Quoted from Sources: – Folic Acid Brain
Genetics Home Reference
Inherent Health – Nutritional Needs Genetic Test
Interleukin Genetics – SpectraCell MTHFR Genotyping Lab Test
nutraMetrix® Isotonix® Activated B-Complex

  • Sharon

    Your information regarding calcium folinate is incomplete. Those with the MTHFR gene mutation cannot use this form, especially those with homozygous C677T are 70% deficient in the ability to process/convert the folinate to L-5-tetrahydrofolinate.

    August 2, 2015 at 6:29 pm
  • KnowMental

    Thanks for the information/update.

    September 13, 2015 at 9:28 pm

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