Mood Stabilizers

Mood Stabilizer

Mood Stabilizers

Mood stabilizers are used to treat Manic-Depressive Disorder (Bipolar), Schizoaffective disorder, Borderline Personality Disorder (BPD), and/or Fibromyalgia, etc.
They suppress mood shifts.

Take the time to research the mood stabilizer prescribed to you:

–  Prescribing Information
–  Boxed Warnings
–  Medication Guide
–  Be aware of any guidelines or warnings if taken in conjunction with other psychiatric medications

Below is a list of mood stabilizers in the U.S.A.

  • Generic Name
    • Brand Name/Registered ® Trademark and their website
      • Pharmaceutical or Marketing company who manufactures/markets the Brand Name

Brands are listed for informational purposes only with no intention of infringement of their Registered ® Trademark/Copyright ©.

Mood stabilizer:

Anticonvulsant Mood stabilizer:

If a brand name is discontinued (no longer made), there may be a number of other pharmaceutical companies that create the generic version or have yet to.

A manufacturer/marketer may have multiple brand names for the same product to market in other countries.  Pharmaceutical companies tend to merge or acquisition each other, therefore the manufacturer/marketer of a brand name can change.

Most mood stabilizers are purely antimanic agents, meaning that they are effective at treating mania and mood cycling and shifting, but are not effective at treating depression.

Exceptions to that rule, because they treat both manic and depressive symptoms, are Lamotrigine and Lithium Carbonate.

Antimanic agents such as Valproic Acid or Carbamazepine cannot treat depression directly as the former two drugs can, but it is thought to help ward off depression in bipolar patients by keeping them out of mania and, thus, preventing their moods from cycling.

Some Atypical Antipsychotics (Risperidone, Olanzapine, Quetiapine, Paliperidone, and Ziprasidone) also have mood stabilizing effects and are thus commonly prescribed even when psychotic symptoms are absent.

Monitoring is required to ensure Lithium levels (concentration in the blood) remain in therapeutic range.

Signs of Lithium toxicity:
ataxia (lack of voluntary coordination of muscle movements)

Possible Lithium Side effects:

weight gain
blurred vision
slight tremble in the hands
feeling of being mildly ill

Lithium treatment has been found to inhibit the enzyme Inositol monophosphatase, leading to lower levels of Inositol triphosphate.  This effect was enhanced further with an Inositol triphosphate re-uptake inhibitor.  Inositol disruptions have been linked to memory impairment and depression.

Use of mood stabilizers and anticonvusants such as Lamotrigine, Carbamazapine, Valproate and others may lead to chronic folate deficiency, potentiating depression.

Folate deficiency may increase the risk of depression and reduce the action of antidepressants.  

L-methylfolate (also formally known as 5-MTHF or Levofolinic acid), a centrally acting trimonoamine modulator, boosts the synthesis of three CNS neurotransmitters: dopamine, norepinephrine and serotonin.

Mood stabilizers and anticonvulsants may interfere with folic acid absorption and L-methylfolate formation.

Augmentation with the medical food L-methylfolate may improve antidepressant effects of these medicines, including Lithium and antidepressants themselves, by boosting the synthesis of antidepressant neurotransmitters.

See the List of Psychiatric Medications we created.

Quoted from Sources: – Mood_stabilizer – Lithium

Featured Image Source: – Lithium

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