Endocannabinoid Signaling

endocannabinoid signaling

Endocannabinoid Signaling

From “The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants” Trends in Pharmacological Sciences/2009 – Laboratory of Neuroendocrinology, The Rockefeller University, New York

“Substantial evidence has accumulated implicating a deficit in endocannabinoid in the etiology of depression; accordingly, pharmacological augmentation of endocannabinoid signaling could be a novel target for the pharmacotherapy of depression.”

“Within preclinical models, facilitation of endocannabinoid neurotransmission evokes both antidepressant and anxiolytic effects. Similar to the actions of conventional antidepressants, enhancement of endocannabinoid signaling can enhance serotonergic and noradrenergic transmission; increase cellular plasticity and neurotrophin expression (brain growth factor) within the hippocampus; and dampen activity within the neuroendocrine stress axis.”

“These preclinical findings support the rationale for the clinical development of agents which inhibit the cellular uptake and/or metabolism of endocannabinoids in the treatment of mood disorders.”

Quoted from Source: – worth repeating marijuana treats anxiety and depression

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