Top
Rapid Acting Antidepressant

Rapid-Acting Antidepressant

UT Southwestern Medical Center researchers have generated fresh insights that could aid in the development of rapid-acting antidepressants for treatment-resistent depression. The researchers found that by blocking NMDA receptors with the drug ketamine, they could elicit rapid antidepressant effects in patients with treatment-resistant depression.  Ketamine was developed as an anesthetic, but is better known publicly for its abuse as the party drug Special K.  Researchers are now seeking alternatives because ketamine can produce side effects that include hallucinations and the potential for abuse -- limiting its utility as an antidepressant. Therefore, researchers had been investigating a drug called memantine, currently FDA-approved for treating moderate to severe Alzheimer's disease, as a potentially promising therapy for treatment-resistant depression.  Memantine acts on the same receptors...

UT Southwestern Medical Center...

Read More
MAOI

MAOI

Monoamine oxidase inhibitors - MAOIs Because of potentially lethal dietary and drug interactions, monoamine oxidase inhibitors have been reserved as a last line of treatment, used only when other classes of antidepressant drugs have failed. MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates (removes/breaks down) serotonin, melatonin, epinephrine, and norepinephrine. MAO-B preferentially deaminates (removes/breaks down) phenylethylamine and trace amines. Dopamine is equally deaminated (removed/broken down) by both types. MAOIs inhibit the catabolism (break down) of dietary amines. If foods containing Tryptophan are consumed, Hyperserotonemia (Serotonin Syndrome) may result. When foods containing Tyramine are consumed, the individual may suffer from hypertensive crisis. It is assumed that tyramine displaces Norepinephrine from the storage vesicles.  This may trigger a cascade in which excessive amounts of Norepinephrine can lead to a hypertensive crisis....

Monoamine oxidase inhibitors ...

Read More
Antidepressant

Antidepressant

Antidepressants are used to treat mood disorders such as Major Depressive Disorder, as well as Anxiety disorders (Panic or Social Anxiety), Obsessive Compulsive Disorders (OCD), Premenstrual Dysphoric Disorder (PMDD), Fibromyalgia, Post Traumatic Stress Disorder (PTSD), and/or Attention Deficit Hyperactivity Disorder (ADHD), etc. Take the time to research the Antidepressant prescribed to you: -  Prescribing Information -  Boxed Warnings -  Medication Guide -  Be aware of any guidelines or warnings if taken in conjunction with other psychiatric medications Below is a list of Antidepressants in the U.S.A. Generic Name Brand Name/Registered ® Trademark and their website Pharmaceutical or Marketing company who manufactures/markets the Brand Name Brands are listed for informational purposes only with no intention of infringement of their Registered ® Trademark/Copyright ©. SSRI - Selective Serotonin Reuptake Inhibitor: Citalopram HBr (Hydrobromide) Celexa ® Forest Pharmaceuticals, Inc. Escitalopram Oxalate Lexapro ® Forest Pharmaceuticals, Inc. Fluoxetine Prozac ® - discontinued Lilly USA, LLC Fluoxetine...

Antidepressants are used to t...

Read More
SSRIs

SSRIs

SSRIs (selective serotonin reuptake inhibitors) are used to treat Depression.  There are so many brands and new ones always surfacing in commercials.  Here is a start to comparing the medications available.   Reference: eMedTV Source: http://depression.emedtv.com/ssris/comparisons-of-ssri-antidepressants.html...

SSRIs (selective serotonin reu...

Read More