Alpha-Stim® CES


Alpha-Stim M modelThe Alpha-Stim®’s proprietary waveform works by moving electrons through the brain at a variety of frequencies, collectively known as harmonic resonance.

With these waveforms, it minimizes the effects of depression, shifts the emotional reactions of anxiety, calms the body to lessen insomnia and diminishes the levels of pain one may be experiencing.  This waveform normalizes the electrical activity of the brain as measured by an electroencephalogram (EEG).


2013 models:

Alpha-Stim M

Alpha-Stim AID

Alpha-Stim® cranial electrotherapy stimulation (CES)

Based on previous and ongoing studies, it appears that the Alpha-Stim® microcurrent waveform activates particular groups of nerve cells that are located at the brainstem.  These groups of nerve cells produce the chemicals serotonin and acetylcholine which can affect the chemical activity of nerve cells that are both nearby and at more distant sites in the nervous system.  In fact, these cells are situated to control the activity of nerve pathways that run up into the brain and that course down into the spinal cord. By changing the electrical and chemical activity of certain nerve cells in the brainstem, Alpha-Stim® technology appears to amplify activity in some neurological systems, and diminish activity in others. This neurological ‘fine tuning’ is called modulation, and occurs either as a result of, or together with the production of a certain type of electrical activity pattern in the brain known as an alpha state which can be measured on brain wave recordings (called electro-encephalograms, abbreviated EEG).  Such alpha rhythms are accompanied by feelings of calmness, relaxation and increased mental focus.  The neurological mechanisms that are occurring during the alpha state appear to decrease stress-effects, reduce agitation and stabilize mood, and regulate both sensations and perceptions of particular types of pain.

Alpha-Stim® CES engages the serotonergic (5-HT) raphe nuclei of the brainstem.  5-HT inhibits brainstem cholinergic (ACh) and noradrenergic (NE) systems that project supratentorially.  This suppresses thalamo-cortical activity, arousal, agitation, alters sensory processing and induces EEG alpha rhythm.  As well, 5-HT can act directly to modulate pain sensation in the dorsal horn of the spinal cord, and alter pain perception, cognition and emotionality within the limbic forebrain.

Alpha-Stim® CES

Blue arrows: inhibitory interactions
Purple arrows: excitatory interactions
X : suppressed pathways/interactions

ACh: actetylcholine;
LDT: laterodorsal tegmental nucleus of the brainstem;
PPN: pediculo-ponitne nucleus of the brainstem;
NE: norepinephrine;
LC: locus ceruleus,
5-HT: serotonin

Quoted from Sources:
How Alpha-Stim® Cranial Electrotherapy Stimulation (CES) Works by James Giordano, Ph.D.
Advanced BioCell is an authorized Alpha-Stim® distributor and consultant.

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